| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 1,727 | 8,581 | 10,381 | |
| 2020 | R | 2,153 | 8,370 | 10,644 | |
| 2016 | R | 2,067 | 7,648 | 9,872 | |
| 2012 | R | 2,817 | 7,075 | 10,033 | |
| 2008 | R | 3,020 | 7,703 | 10,944 | |
| 2004 | R | 3,327 | 6,538 | 9,932 | |
| 2000 | R | 3,287 | 5,101 | 8,482 | |
| 1996 | R | 3,053 | 3,473 | 7,127 | |
| 1992 | R | 3,385 | 4,317 | 8,526 | |
| 1988 | R | 3,429 | 4,348 | 7,892 | |
| 1984 | R | 2,897 | 4,821 | 7,732 | |
| 1980 | D | 4,832 | 3,264 | 8,178 | |
| 1976 | D | 4,431 | 2,362 | 6,977 | |
| 1972 | R | 398 | 4,607 | 5,056 | |
| 1968 | R | 440 | 723 | 6,218 | |
| 1964 | R | 1,013 | 2,289 | 3,302 | |
| 1960 | D | 1,777 | 740 | 2,985 | |
| 1956 | D | 1,942 | 383 | 2,399 | |
| 1952 | D | 2,672 | 731 | 3,403 | |
| 1948 | D | 602 | 74 | 1,665 | |
| 1944 | D | 1,652 | 175 | 1,827 | |
| 1940 | D | 2,117 | 118 | 2,235 | |
| 1936 | D | 1,809 | 50 | 1,863 | |
| 1932 | D | 1,976 | 76 | 2,052 | |
| 1928 | D | 1,366 | 269 | 1,635 | |
| 1924 | D | 1,225 | 179 | 1,406 | |
| 1920 | D | 992 | 496 | 1,537 | |
| 1916 | D | 1,342 | 164 | 1,538 | |
| 1912 | D | 839 | 85 | 1,098 | |
| 1908 | — | — | — | — | |
| 1904 | — | — | — | — | |
| 1900 | D | 902 | 210 | 1,131 | |
| 1896 | D | 973 | 59 | 1,054 | |
| 1892 | D | 633 | 51 | 938 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Prentiss County, tucked in Mississippi's northeastern corner, has delivered lopsided Republican margins for over a decade, reflecting the deep-red alignment common across rural hill-country counties where white working-class voters dominate the electorate.
The unraveling was not abrupt. The Democratic margin in Prentiss County peaked at ninety-four points in 1936; it narrowed steadily over the late twentieth century. The 1984 election delivered the county to the Republican party for the first time in many years, by a margin of twenty-five points. By 2024, the margin had widened further.
The economic and demographic context is severe. Prentiss County's median household income of $49,724 is among the lowest of any county in the United States; 17% of residents live below the federal poverty line. The county's voting pattern over the last decade is most similar to that of Lamar County and Itawamba County.