| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 3,574 | 6,963 | 10,717 | |
| 2020 | R | 4,558 | 7,296 | 12,342 | |
| 2016 | R | 5,670 | 7,061 | 12,912 | |
| 2012 | R | 6,467 | 6,603 | 13,375 | |
| 2008 | R | 6,667 | 6,976 | 14,010 | |
| 2004 | D | 7,593 | 6,121 | 14,153 | |
| 2000 | D | 7,107 | 5,199 | 12,586 | |
| 1996 | D | 8,301 | 3,919 | 13,347 | |
| 1992 | D | 10,046 | 4,697 | 15,962 | |
| 1988 | R | 6,759 | 7,841 | 14,888 | |
| 1984 | R | 7,548 | 10,180 | 17,766 | |
| 1980 | D | 8,908 | 7,170 | 16,417 | |
| 1976 | D | 10,292 | 6,009 | 16,328 | |
| 1972 | R | 3,544 | 10,931 | 14,627 | |
| 1968 | D | 4,993 | 4,369 | 15,509 | |
| 1964 | D | 8,678 | 6,213 | 14,911 | |
| 1960 | D | 5,138 | 4,983 | 10,585 | |
| 1956 | D | 6,428 | 4,269 | 10,955 | |
| 1952 | D | 6,968 | 4,586 | 11,567 | |
| 1948 | D | 3,763 | 771 | 6,335 | |
| 1944 | D | 3,938 | 1,292 | 5,235 | |
| 1940 | D | 5,257 | 616 | 5,891 | |
| 1936 | D | 4,835 | 303 | 5,147 | |
| 1932 | D | 5,776 | 364 | 6,203 | |
| 1928 | D | 4,451 | 1,324 | 5,799 | |
| 1924 | D | 2,039 | 703 | 2,828 | |
| 1920 | D | 1,809 | 1,050 | 2,980 | |
| 1916 | D | 1,249 | 417 | 1,666 | |
| 1912 | D | 767 | 263 | 1,300 | |
| 1908 | R | 930 | 1,167 | 2,263 | |
| 1904 | D | 689 | 417 | 1,115 | |
| 1900 | D | 591 | 378 | 969 | |
| 1896 | D | 815 | 168 | 985 | |
| 1892 | D | 777 | 525 | 1,302 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Mississippi County sits in Arkansas's northeastern corner along the river's edge, a predominantly rural, agriculture-heavy area where Republican presidential margins have widened steadily over the past two decades, reaching 31.6 points in 2024.
The shift began with civil rights. 2008 marked the realignment in Mississippi County, by a two points margin. The Republican margin reached its widest at fifty-one points in 1972. The 2024 margin was thirty-two points.
The political shift has tracked, in Mississippi County, the political shift of the South more broadly. A 57% non-Hispanic-white share, a median household income of $52,548, and a 21% poverty rate describe the demographic context. The county's voting pattern over the last decade is most similar to that of Benton County and Hardeman County.
