| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 3,525 | 13,786 | 17,480 | |
| 2020 | R | 3,753 | 13,769 | 17,748 | |
| 2016 | R | 3,575 | 13,168 | 17,337 | |
| 2012 | R | 5,122 | 11,623 | 16,999 | |
| 2008 | R | 6,258 | 11,563 | 18,026 | |
| 2004 | R | 6,057 | 11,330 | 17,448 | |
| 2000 | R | 6,452 | 8,999 | 15,704 | |
| 1996 | D | 7,011 | 6,641 | 15,252 | |
| 1992 | D | 7,452 | 6,265 | 16,507 | |
| 1988 | R | 5,914 | 8,013 | 13,948 | |
| 1984 | R | 5,569 | 8,727 | 14,296 | |
| 1980 | R | 6,854 | 8,227 | 15,336 | |
| 1976 | D | 8,075 | 5,473 | 13,576 | |
| 1972 | R | 3,646 | 7,316 | 10,962 | |
| 1968 | D | 4,313 | 3,856 | 10,643 | |
| 1964 | D | 7,512 | 3,212 | 10,724 | |
| 1960 | D | 6,349 | 5,807 | 12,156 | |
| 1956 | D | 6,683 | 4,654 | 11,337 | |
| 1952 | D | 7,127 | 4,661 | 11,814 | |
| 1948 | D | 8,266 | 2,519 | 10,803 | |
| 1944 | D | 7,132 | 3,995 | 11,168 | |
| 1940 | D | 7,899 | 4,401 | 12,342 | |
| 1936 | D | 7,763 | 3,126 | 10,941 | |
| 1932 | D | 6,948 | 2,310 | 9,333 | |
| 1928 | D | 5,159 | 3,779 | 8,944 | |
| 1924 | D | 3,633 | 3,335 | 8,226 | |
| 1920 | R | 4,157 | 4,204 | 8,579 | |
| 1916 | D | 2,816 | 2,285 | 5,341 | |
| 1912 | D | 1,945 | 1,235 | 4,187 | |
| 1908 | D | 1,853 | 1,473 | 4,004 | |
| 1904 | D | 1,470 | 1,124 | 2,679 | |
| 1900 | D | 1,706 | 821 | 2,560 | |
| 1896 | D | 1,906 | 751 | 2,662 | |
| 1892 | D | 1,612 | 671 | 2,341 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Scott County, anchored by Sikeston in the Missouri Bootheel, voted Republican by nearly 59 points in 2024, reflecting the region's sharp rightward shift over the past two decades as rural white working-class voters consolidated behind the GOP.
The unraveling was not abrupt. The Democratic margin in Scott County peaked at fifty-three points in 1948; it narrowed steadily over the late twentieth century. The 2000 election delivered the county to the Republican party for the first time in many years, by a margin of sixteen points. By 2024, the margin had widened further.
The economic and demographic context is severe. Scott County's median household income of $62,782 is among the lowest of any county in the United States; 13% of residents live below the federal poverty line. The county's voting pattern over the last decade is most similar to that of Callaway County and Logan County.