| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 6,811 | 21,521 | 28,698 | |
| 2020 | R | 7,044 | 20,511 | 28,065 | |
| 2016 | R | 6,250 | 17,468 | 24,920 | |
| 2012 | R | 8,829 | 13,248 | 22,705 | |
| 2008 | R | 11,540 | 12,660 | 24,550 | |
| 2004 | R | 10,748 | 12,087 | 22,933 | |
| 2000 | R | 9,075 | 9,327 | 18,841 | |
| 1996 | D | 9,034 | 6,200 | 17,726 | |
| 1992 | D | 9,367 | 5,889 | 18,947 | |
| 1988 | D | 8,158 | 7,923 | 16,127 | |
| 1984 | R | 7,137 | 9,792 | 16,929 | |
| 1980 | R | 7,495 | 8,914 | 16,916 | |
| 1976 | D | 8,852 | 7,002 | 15,911 | |
| 1972 | R | 4,658 | 8,812 | 13,470 | |
| 1968 | R | 6,379 | 7,492 | 15,738 | |
| 1964 | D | 10,567 | 5,690 | 16,257 | |
| 1960 | R | 7,205 | 10,131 | 17,336 | |
| 1956 | R | 7,566 | 9,968 | 17,534 | |
| 1952 | R | 8,040 | 9,672 | 17,729 | |
| 1948 | D | 7,276 | 6,234 | 13,542 | |
| 1944 | R | 6,745 | 7,320 | 14,076 | |
| 1940 | R | 8,132 | 8,687 | 16,851 | |
| 1936 | D | 7,876 | 7,271 | 15,213 | |
| 1932 | D | 7,613 | 6,017 | 13,804 | |
| 1928 | R | 4,171 | 9,040 | 13,228 | |
| 1924 | R | 5,542 | 6,117 | 11,956 | |
| 1920 | R | 5,300 | 5,504 | 11,039 | |
| 1916 | D | 3,675 | 3,015 | 6,885 | |
| 1912 | D | 2,786 | 2,305 | 6,225 | |
| 1908 | R | 2,942 | 3,260 | 6,713 | |
| 1904 | R | 2,615 | 2,894 | 5,647 | |
| 1900 | D | 2,707 | 2,295 | 5,066 | |
| 1896 | D | 2,245 | 1,664 | 3,927 | |
| 1892 | D | 2,141 | 1,253 | 3,430 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
St. Francois County's Ozark foothills economy traces back to lead mining, and its working-class white electorate has shifted sharply rightward over two decades — the 2024 presidential margin of R+51 reflects one of the steepest partisan realignments in the state.
The Democratic margin in St. Francois County peaked at thirty points in 1964. By 2000 the county had flipped, voting Republican for the first time in many years. The 2024 margin was fifty-one points, the most Republican-leaning result in the county's modern history.
The economic context is the key. St. Francois County's median household income of $57,477 sits well below state and national norms, and 16% of residents live below the federal poverty line. The shift here is part of a broader realignment of working-class places across the country. The county's voting pattern over the last decade is most similar to that of Jersey County and Randolph County.