| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 1,331 | 3,917 | 5,278 | |
| 2020 | R | 1,560 | 4,120 | 5,735 | |
| 2016 | R | 1,947 | 3,964 | 6,043 | |
| 2012 | R | 2,671 | 3,598 | 6,335 | |
| 2008 | R | 3,029 | 3,954 | 7,047 | |
| 2004 | R | 3,381 | 3,398 | 6,806 | |
| 2000 | D | 3,245 | 2,750 | 6,060 | |
| 1996 | D | 3,371 | 1,820 | 5,677 | |
| 1992 | D | 3,924 | 2,161 | 6,768 | |
| 1988 | D | 3,288 | 3,066 | 6,364 | |
| 1984 | R | 3,293 | 3,733 | 7,026 | |
| 1980 | D | 4,140 | 3,519 | 7,732 | |
| 1976 | D | 4,681 | 2,541 | 7,236 | |
| 1972 | R | 2,017 | 4,697 | 6,714 | |
| 1968 | D | 2,681 | 2,191 | 7,822 | |
| 1964 | D | 5,083 | 2,658 | 7,741 | |
| 1960 | D | 7,312 | 4,464 | 11,776 | |
| 1956 | D | 8,064 | 3,969 | 12,033 | |
| 1952 | D | 8,913 | 4,118 | 13,043 | |
| 1948 | D | 10,269 | 2,249 | 12,526 | |
| 1944 | D | 7,380 | 4,333 | 11,733 | |
| 1940 | D | 9,391 | 6,011 | 15,453 | |
| 1936 | D | 8,171 | 4,139 | 12,324 | |
| 1932 | D | 7,909 | 4,415 | 12,356 | |
| 1928 | R | 5,259 | 6,256 | 11,515 | |
| 1924 | D | 5,616 | 4,811 | 10,573 | |
| 1920 | R | 3,901 | 4,443 | 8,453 | |
| 1916 | D | 2,447 | 2,076 | 4,621 | |
| 1912 | D | 1,617 | 973 | 3,164 | |
| 1908 | D | 1,725 | 1,390 | 3,164 | |
| 1904 | D | 1,375 | 923 | 2,343 | |
| 1900 | D | 1,370 | 655 | 2,032 | |
| 1896 | D | 1,260 | 355 | 1,618 | |
| 1892 | D | 700 | 133 | 845 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Pemiscot County sits at the southernmost tip of Missouri's Bootheel, a region shaped by Mississippi Delta agriculture and persistent poverty. Its presidential margins have widened steadily over two decades, reflecting a rural realignment common across the mid-South.
The unraveling was not abrupt. The Democratic margin in Pemiscot County peaked at sixty-seven points in 1892; it narrowed steadily over the late twentieth century. The 2004 election delivered the county to the Republican party for the first time in many years, by a margin of zero points. By 2024, the margin had widened further.
The economic and demographic context is severe. Pemiscot County's median household income of $40,089 is among the lowest of any county in the United States; 30% of residents live below the federal poverty line. The county's voting pattern over the last decade is most similar to that of Van Buren County and New Madrid County.