| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 1,481 | 6,300 | 7,839 | |
| 2020 | R | 1,662 | 6,076 | 7,836 | |
| 2016 | R | 1,548 | 5,798 | 7,560 | |
| 2012 | R | 2,309 | 4,701 | 7,160 | |
| 2008 | R | 2,784 | 4,586 | 7,474 | |
| 2004 | R | 2,856 | 4,673 | 7,570 | |
| 2000 | R | 2,817 | 4,232 | 7,175 | |
| 1996 | D | 2,937 | 2,634 | 6,480 | |
| 1992 | D | 3,194 | 2,256 | 7,164 | |
| 1988 | R | 3,215 | 3,406 | 6,639 | |
| 1984 | R | 3,037 | 4,542 | 7,579 | |
| 1980 | R | 3,578 | 4,430 | 8,187 | |
| 1976 | D | 4,296 | 3,360 | 7,688 | |
| 1972 | R | 2,844 | 4,538 | 7,382 | |
| 1968 | R | 3,462 | 3,804 | 8,087 | |
| 1964 | D | 5,389 | 2,837 | 8,226 | |
| 1960 | R | 4,208 | 4,925 | 9,133 | |
| 1956 | R | 4,337 | 4,694 | 9,031 | |
| 1952 | R | 4,577 | 5,537 | 10,129 | |
| 1948 | D | 5,193 | 3,833 | 9,039 | |
| 1944 | R | 4,772 | 4,796 | 9,581 | |
| 1940 | D | 6,120 | 5,384 | 11,519 | |
| 1936 | D | 6,417 | 4,808 | 11,262 | |
| 1932 | D | 6,370 | 3,266 | 9,718 | |
| 1928 | R | 4,838 | 5,618 | 10,510 | |
| 1924 | D | 5,538 | 4,909 | 10,950 | |
| 1920 | R | 5,626 | 6,309 | 12,192 | |
| 1916 | D | 3,805 | 3,034 | 7,063 | |
| 1912 | D | 3,610 | 1,288 | 6,985 | |
| 1908 | D | 3,919 | 3,542 | 7,724 | |
| 1904 | R | 3,604 | 3,674 | 7,567 | |
| 1900 | D | 4,174 | 3,568 | 7,988 | |
| 1896 | D | 4,473 | 3,475 | 8,006 | |
| 1892 | D | 3,284 | 2,746 | 6,814 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Macon County's R+61.5 margin in 2024 places it among Missouri's most lopsided presidential results, reflecting the deep rural realignment that has reshaped small agricultural counties across the state over the past two decades.
The Republican margin in Macon County reached its widest at sixty-one points in 2024. The margin in 2024 was sixty-one points, in line with the county's deep historical pattern.
Macon County's loyalty is rooted in its place. Median household income of $62,357, a 92% non-Hispanic-white share, and a population of 15,163 together describe a community whose political habits are deeply settled. The county's voting pattern over the last decade is most similar to that of Daviess County and Shelby County.
