| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 3,625 | 11,236 | 15,123 | |
| 2020 | R | 4,067 | 11,655 | 16,011 | |
| 2016 | R | 3,772 | 11,077 | 15,602 | |
| 2012 | R | 5,228 | 9,612 | 15,145 | |
| 2008 | R | 7,569 | 8,639 | 16,424 | |
| 2004 | R | 5,649 | 9,990 | 15,746 | |
| 2000 | R | 6,300 | 8,485 | 15,054 | |
| 1996 | D | 7,003 | 6,395 | 15,532 | |
| 1992 | D | 6,718 | 6,683 | 17,284 | |
| 1988 | R | 7,006 | 9,813 | 16,881 | |
| 1984 | R | 6,417 | 10,872 | 17,459 | |
| 1980 | R | 7,829 | 10,083 | 18,822 | |
| 1976 | D | 9,612 | 9,100 | 18,860 | |
| 1972 | R | 6,089 | 11,940 | 18,196 | |
| 1968 | R | 7,297 | 8,369 | 17,818 | |
| 1964 | D | 12,678 | 7,612 | 20,411 | |
| 1960 | R | 9,918 | 11,490 | 21,516 | |
| 1956 | R | 8,691 | 13,047 | 21,801 | |
| 1952 | R | 9,384 | 12,786 | 22,316 | |
| 1948 | D | 11,650 | 9,250 | 21,182 | |
| 1944 | D | 10,297 | 10,023 | 20,463 | |
| 1940 | D | 12,265 | 11,211 | 23,590 | |
| 1936 | D | 13,669 | 8,589 | 22,400 | |
| 1932 | D | 14,084 | 6,590 | 21,140 | |
| 1928 | R | 9,837 | 10,035 | 20,104 | |
| 1924 | D | 8,603 | 8,493 | 19,168 | |
| 1920 | R | 8,052 | 10,011 | 19,479 | |
| 1916 | D | 5,380 | 4,805 | 11,364 | |
| 1912 | D | 4,448 | 2,805 | 9,752 | |
| 1908 | D | 5,116 | 4,247 | 9,985 | |
| 1904 | R | 4,093 | 4,278 | 8,923 | |
| 1900 | D | 4,443 | 3,554 | 8,212 | |
| 1896 | D | 4,349 | 3,480 | 7,932 | |
| 1892 | D | 3,417 | 2,653 | 6,835 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Knox County, anchored by Vincennes on the Wabash River, swung to R+50.4 in 2024 — a margin typical of deep-rural southwestern Indiana, where manufacturing decline and agricultural identity have steadily reshaped the electorate over two decades.
The Republican margin in Knox County reached its widest at fifty points in 2024. The margin in 2024 was fifty points, in line with the county's deep historical pattern.
Knox County's loyalty is rooted in its place. Median household income of $61,237, a 90% non-Hispanic-white share, and a population of 36,007 together describe a community whose political habits are deeply settled. The county's voting pattern over the last decade is most similar to that of Edgar County and Crawford County.
