| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 4,181 | 12,961 | 17,374 | |
| 2020 | R | 4,873 | 13,064 | 18,176 | |
| 2016 | R | 4,146 | 11,546 | 16,277 | |
| 2012 | R | 6,027 | 8,855 | 15,168 | |
| 2008 | R | 6,621 | 8,849 | 15,798 | |
| 2004 | R | 7,630 | 8,696 | 16,435 | |
| 2000 | R | 7,164 | 7,233 | 14,663 | |
| 1996 | D | 6,883 | 5,370 | 13,956 | |
| 1992 | D | 7,214 | 4,975 | 14,414 | |
| 1988 | D | 6,956 | 6,559 | 13,558 | |
| 1984 | R | 6,923 | 7,451 | 14,462 | |
| 1980 | D | 7,126 | 6,857 | 14,275 | |
| 1976 | D | 6,880 | 5,062 | 12,013 | |
| 1972 | R | 4,491 | 6,828 | 11,437 | |
| 1968 | R | 4,689 | 4,698 | 10,755 | |
| 1964 | D | 6,680 | 4,045 | 10,764 | |
| 1960 | R | 5,245 | 6,101 | 11,346 | |
| 1956 | R | 5,045 | 5,464 | 10,538 | |
| 1952 | D | 4,716 | 4,354 | 9,078 | |
| 1948 | D | 4,186 | 3,168 | 7,406 | |
| 1944 | D | 3,821 | 3,718 | 7,542 | |
| 1940 | D | 4,742 | 4,059 | 8,825 | |
| 1936 | D | 4,686 | 3,973 | 8,659 | |
| 1932 | D | 4,963 | 3,422 | 8,492 | |
| 1928 | R | 2,435 | 4,410 | 6,845 | |
| 1924 | R | 1,932 | 2,510 | 5,306 | |
| 1920 | R | 2,754 | 3,111 | 5,963 | |
| 1916 | R | 1,820 | 1,821 | 3,765 | |
| 1912 | D | 1,172 | 923 | 3,227 | |
| 1908 | R | 1,441 | 2,142 | 3,738 | |
| 1904 | R | 1,112 | 2,005 | 3,233 | |
| 1900 | R | 1,430 | 1,982 | 3,450 | |
| 1896 | R | 1,369 | 1,802 | 3,238 | |
| 1892 | R | 1,109 | 1,143 | 2,290 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Greenup County sits along the Ohio River in Kentucky's historically Democratic coalfields region, yet by 2024 it swung to a 50-point Republican presidential margin — a realignment that tracks closely with the broader collapse of Democratic support across Appalachian Kentucky.
The Republican margin in Greenup County reached its widest at fifty-one points in 2024. The margin in 2024 was fifty-one points, in line with the county's deep historical pattern.
Greenup County's loyalty is rooted in its place. Median household income of $60,751, a 95% non-Hispanic-white share, and a population of 35,501 together describe a community whose political habits are deeply settled. The county's voting pattern over the last decade is most similar to that of Boyd County and Clinton County.