| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 4,736 | 6,987 | 11,972 | |
| 2020 | R | 4,992 | 7,027 | 12,327 | |
| 2016 | R | 5,288 | 6,795 | 13,144 | |
| 2012 | R | 5,967 | 6,147 | 12,454 | |
| 2008 | D | 6,783 | 6,055 | 13,042 | |
| 2004 | R | 7,119 | 7,656 | 14,929 | |
| 2000 | R | 6,080 | 6,465 | 13,012 | |
| 1996 | D | 5,632 | 5,049 | 12,035 | |
| 1992 | D | 5,814 | 5,297 | 13,922 | |
| 1988 | R | 5,247 | 7,173 | 12,493 | |
| 1984 | R | 4,561 | 9,383 | 14,001 | |
| 1980 | R | 4,093 | 8,995 | 14,589 | |
| 1976 | R | 5,464 | 9,683 | 15,534 | |
| 1972 | R | 5,143 | 10,573 | 15,738 | |
| 1968 | R | 3,785 | 8,496 | 12,924 | |
| 1964 | R | 6,144 | 6,907 | 13,051 | |
| 1960 | R | 4,520 | 9,363 | 13,893 | |
| 1956 | R | 3,872 | 9,725 | 13,605 | |
| 1952 | R | 3,922 | 10,126 | 14,053 | |
| 1948 | R | 4,206 | 8,058 | 12,373 | |
| 1944 | R | 4,497 | 9,028 | 13,616 | |
| 1940 | R | 5,783 | 10,326 | 16,217 | |
| 1936 | R | 7,138 | 8,723 | 16,012 | |
| 1932 | D | 7,608 | 6,329 | 14,105 | |
| 1928 | R | 4,104 | 8,953 | 13,138 | |
| 1924 | R | 4,016 | 7,505 | 12,306 | |
| 1920 | R | 3,930 | 7,221 | 11,430 | |
| 1916 | R | 5,740 | 7,192 | 13,546 | |
| 1912 | D | 2,959 | 1,876 | 6,973 | |
| 1908 | R | 3,112 | 3,733 | 7,312 | |
| 1904 | R | 2,730 | 4,041 | 7,299 | |
| 1900 | R | 3,444 | 4,076 | 7,733 | |
| 1896 | R | 3,684 | 4,036 | 7,889 | |
| 1892 | R | 3,237 | 3,319 | 7,103 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Home to Western Illinois University in Macomb, McDonough County pairs a modest college-town influence with a predominantly rural, farm-economy electorate that produced an R+18.8 presidential margin in 2024.
The county's recent history is a story of close margins. The Democratic margin reached sixteen points in 1912; the Republican margin reached forty-four points in 1952. Most other elections have been decided by single-digit points.
McDonough County's demographics — a population of 26,920, a 86% non-Hispanic-white share, a median household income of $52,795 — situate the county close to national averages on several dimensions. The county's voting pattern over the last decade is most similar to that of Kankakee County and Lenawee County.
