| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 2,629 | 7,031 | 9,803 | |
| 2020 | R | 2,713 | 6,630 | 9,498 | |
| 2016 | R | 2,542 | 5,496 | 8,512 | |
| 2012 | R | 3,813 | 4,055 | 8,070 | |
| 2008 | D | 4,979 | 3,732 | 8,825 | |
| 2004 | D | 4,281 | 3,791 | 8,146 | |
| 2000 | D | 3,600 | 3,505 | 7,311 | |
| 1996 | D | 3,597 | 2,078 | 6,727 | |
| 1992 | D | 3,795 | 1,780 | 7,137 | |
| 1988 | D | 3,612 | 2,532 | 6,164 | |
| 1984 | R | 2,723 | 3,245 | 5,968 | |
| 1980 | D | 3,324 | 2,768 | 6,291 | |
| 1976 | D | 3,091 | 2,241 | 5,372 | |
| 1972 | R | 2,247 | 2,900 | 5,147 | |
| 1968 | D | 2,225 | 1,937 | 4,602 | |
| 1964 | D | 3,768 | 1,316 | 5,084 | |
| 1960 | D | 3,211 | 1,956 | 5,167 | |
| 1956 | R | 2,363 | 2,633 | 4,996 | |
| 1952 | R | 2,385 | 2,682 | 5,069 | |
| 1948 | D | 1,984 | 1,567 | 3,568 | |
| 1944 | R | 1,878 | 2,214 | 4,098 | |
| 1940 | R | 2,098 | 2,750 | 4,856 | |
| 1936 | D | 2,446 | 1,664 | 4,182 | |
| 1932 | D | 3,087 | 1,109 | 4,215 | |
| 1928 | D | 2,547 | 1,099 | 3,652 | |
| 1924 | R | 1,257 | 1,330 | 2,703 | |
| 1920 | R | 1,149 | 1,917 | 3,088 | |
| 1916 | D | 1,218 | 1,137 | 2,372 | |
| 1912 | D | 1,138 | 1,100 | 2,312 | |
| 1908 | D | 1,108 | 1,064 | 2,181 | |
| 1904 | D | 1,163 | 986 | 2,167 | |
| 1900 | D | 1,296 | 935 | 2,246 | |
| 1896 | D | 1,245 | 903 | 2,153 | |
| 1892 | D | 1,155 | 683 | 1,897 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Ste. Genevieve County, anchored by Missouri's oldest European settlement, has shifted decisively toward Republican presidential candidates over the past two decades, with 2024 marking one of its widest recorded margins despite a modest rural population.
The 2012 election was the turning point, when the Republican candidate carried the county by three points. The 2024 margin was forty-five points, in line with the county's new direction.
The demographics suggest why. A population of 18,571, a 94% non-Hispanic-white share, and a median household income of $66,339 situate the county in the broader realignment patterns of recent cycles. The county's voting pattern over the last decade is most similar to that of Monroe County and Macoupin County.
