| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | D | 171,118 | 109,077 | 285,053 | |
| 2020 | D | 173,086 | 107,294 | 284,486 | |
| 2016 | D | 149,248 | 98,062 | 257,405 | |
| 2012 | D | 146,365 | 104,789 | 253,852 | |
| 2008 | D | 142,101 | 97,718 | 241,771 | |
| 2004 | D | 100,042 | 98,254 | 199,314 | |
| 2000 | D | 84,394 | 80,787 | 166,264 | |
| 1996 | D | 69,208 | 67,727 | 147,587 | |
| 1992 | D | 66,319 | 60,140 | 146,399 | |
| 1988 | R | 50,351 | 66,060 | 117,232 | |
| 1984 | R | 46,027 | 73,096 | 119,336 | |
| 1980 | R | 44,516 | 53,291 | 102,622 | |
| 1976 | D | 46,826 | 45,441 | 92,740 | |
| 1972 | R | 25,800 | 61,381 | 88,366 | |
| 1968 | R | 25,604 | 38,996 | 84,351 | |
| 1964 | D | 39,969 | 35,635 | 75,604 | |
| 1960 | R | 30,486 | 41,357 | 71,843 | |
| 1956 | R | 21,948 | 32,751 | 54,699 | |
| 1952 | R | 29,028 | 33,310 | 62,338 | |
| 1948 | D | 17,224 | 14,167 | 35,349 | |
| 1944 | D | 23,495 | 12,962 | 36,457 | |
| 1940 | D | 26,565 | 9,770 | 36,335 | |
| 1936 | D | 25,579 | 9,514 | 35,093 | |
| 1932 | D | 19,301 | 9,263 | 29,059 | |
| 1928 | R | 9,872 | 16,541 | 26,413 | |
| 1924 | D | 8,804 | 6,822 | 15,943 | |
| 1920 | D | 9,615 | 7,920 | 17,535 | |
| 1916 | D | 4,616 | 3,670 | 8,330 | |
| 1912 | D | 3,830 | 460 | 6,338 | |
| 1908 | D | 3,822 | 2,863 | 6,758 | |
| 1904 | D | 2,763 | 1,716 | 4,500 | |
| 1900 | D | 3,335 | 3,296 | 6,676 | |
| 1896 | D | 3,479 | 3,455 | 7,004 | |
| 1892 | D | 2,773 | 2,532 | 5,979 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Home to several historically Black colleges and universities, Guilford County has voted Democratic in every presidential race since 2008, with margins widening as its urban core grows relative to surrounding rural precincts.
The Democratic margin in Guilford County has been steady. It reached its modern peak at fifty-three points in 1912; the 2024 margin was twenty-two points, still in line with the county's long pattern.
Guilford County's political identity is inseparable from its demographic profile: a 48% non-Hispanic-white share, a median household income of $68,642, and the full diversity of a major metropolitan center. The county's voting pattern resembles other major urban centers most closely — Mecklenburg County and Montgomery County.
