| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 287 | 296 | 622 | |
| 2020 | D | 353 | 308 | 676 | |
| 2016 | D | 395 | 298 | 699 | |
| 2012 | D | 479 | 302 | 787 | |
| 2008 | D | 579 | 364 | 950 | |
| 2004 | D | 516 | 439 | 970 | |
| 2000 | D | 555 | 366 | 941 | |
| 1996 | D | 546 | 269 | 873 | |
| 1992 | D | 550 | 298 | 990 | |
| 1988 | D | 511 | 424 | 973 | |
| 1984 | R | 501 | 512 | 1,034 | |
| 1980 | D | 598 | 349 | 968 | |
| 1976 | D | 567 | 325 | 954 | |
| 1972 | R | 395 | 701 | 1,153 | |
| 1968 | D | 527 | 44 | 1,105 | |
| 1964 | R | 34 | 456 | 490 | |
| 1960 | D | 178 | 64 | 423 | |
| 1956 | D | 172 | 42 | 289 | |
| 1952 | D | 170 | 127 | 297 | |
| 1948 | D | 11 | 5 | 225 | |
| 1944 | D | 215 | 5 | 220 | |
| 1940 | D | 218 | 9 | 227 | |
| 1936 | D | 214 | 0 | 214 | |
| 1932 | D | 159 | 1 | 160 | |
| 1928 | D | 134 | 6 | 140 | |
| 1924 | D | 126 | 17 | 143 | |
| 1920 | D | 83 | 13 | 96 | |
| 1916 | D | 94 | 8 | 105 | |
| 1912 | D | 99 | 3 | 111 | |
| 1908 | — | — | — | — | |
| 1904 | — | — | — | — | |
| 1900 | D | 84 | 17 | 101 | |
| 1896 | D | 97 | 29 | 128 | |
| 1892 | D | 119 | 25 | 145 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Issaquena County, hugging the Mississippi River delta, is the state's smallest county by population — yet its near-even 2024 presidential split makes it a persistent outlier in a state that otherwise tilts heavily in one direction.
The county's recent history is a story of close margins. The Democratic margin reached 100 points in 1936; the Republican margin reached eighty-six points in 1964. Most other elections have been decided by single-digit points.
Issaquena County's demographics — a population of 928, a 34% non-Hispanic-white share, a median household income of $31,429 — situate the county close to national averages on several dimensions. The county's voting pattern over the last decade is most similar to that of Surry County and Marlboro County.